These color changes could indicate that you have serious bleeding inside of your body. However, sudden drops in blood pressure may be a symptom of serious internal bleeding, which is a possible side effect of Plavix. They can check your blood pressure and let you know if you need any medical treatment.
But if you have symptoms of low blood pressure that feel life threatening, call Shortness of breath is not a common side effect of Plavix, but it may be symptom of a serious side effect of the drug. Plavix is used to help prevent blood clots from forming in your body. Shortness of breath can be a sign of a dangerous side effect called thrombotic thrombocytopenic purpura TTP.
With TTP, blood clots are formed throughout your body. Some blood clots can form in your arms or legs and then travel to your lungs. Once inside your lungs, the clot can block the flow of blood to your lung tissue.
This condition is known as pulmonary embolism PE. Symptoms of PE can include shortness of breath and chest pain. This condition is very dangerous and can be life threatening.
Stomach pain is not a common side effect of Plavix. Serious bleeding is a possible side effect of Plavix. Stomach pain can also be a sign of a dangerous side effect called thrombotic thrombocytopenic purpura TTP. With TTP, blood clots are formed throughout your body, including in your small blood vessels. Plavix is FDA-approved to reduce the risk of heart attack and stroke in people with certain cardiovascular conditions.
These conditions are described below. Plavix is approved to reduce the risk of heart attack and stroke in people with acute coronary syndrome ACS , which includes these three conditions:.
These conditions are typically caused by coronary artery disease CAD. Sometimes plaques are made of cholesterol. Plaque formation causes your arteries to be partly or fully blocked, not allowing enough blood to flow through them. The lack of blood flow results in a lack of oxygen to your heart. In clinical studies of people admitted to the hospital with ACS, people were given aspirin and either Plavix or a placebo treatment with no active drug.
After up to 1 year of treatment, people using Plavix had fewer severe ACS complications than people who took the placebo. For details, see the Plavix package insert. This results in a lack of oxygen in your heart muscle and causes damage in your heart. Plavix has been shown to reduce this risk in people using the drug.
A clinical study compared the use of Plavix versus aspirin in preventing heart attack, stroke, or cardiovascular-related death. After up to 3 years of treatment, fewer people taking Plavix had these serious effects. The blocked blood flow results in a lack of oxygen to your brain. Plavix is approved to prevent heart attack and stroke in people with peripheral artery disease PAD. With PAD, your arteries are narrowed. This results in less blood flow to certain areas of your body, such as your arms and legs.
With PAD, your arteries typically become narrowed by a buildup of plaque inside of them. Sometimes plaque is made from cholesterol.
The buildup causes your vessels to be either partly or fully blocked. People with PAD have a higher risk of cardiovascular events, such as heart attack and stroke. Plavix has been shown to reduce the risk of heart attack, stroke or cardiovascular-related death in people who have PAD. People were given either Plavix or aspirin for up to 3 years. Compared with those taking aspirin, fewer people taking Plavix had a stroke or heart attack.
But there was no difference between the two treatment groups for the percentage of people who died from cardiovascular events. In addition to the uses listed above, Plavix may be used off-label. And you may wonder if Plavix is used for certain other conditions.
CABG is a type of open-heart surgery that helps improve blood flow to your heart. During CABG surgery, an artery or vein is taken from one part of your body such as your leg. This way, blood can flow into an area of heart muscle that would otherwise be blocked from blood flow. The combination of drugs may also help to keep the newly grafted vessel flexible. Stents are mesh tubes that are sometimes placed into your arteries to keep the arteries open. Stents are usually placed when someone has a blockage in their artery that is stopping blood from flowing through the artery.
This drug helps to reduce the risk of a blood clot forming inside the stent. However, Plavix is also sometimes prescribed for a while after a stent is placed. The length of Plavix treatment depends on if the stent placed is a drug-eluting stent a stent that gives off a drug or a bare metal stent.
Atrial fibrillation is a type of heart arrythmia abnormal rate or rhythm of your heart beat. People with atrial fibrillation have a higher risk of blood clots forming inside their heart.
This is because their heart is not pumping their blood properly. Blood clots are dangerous because they can travel inside your body and may get trapped in smaller vessels. If this happens, the clots can cut off blood flow to your heart, lungs, or brain.
Sometimes, Plavix is prescribed to help prevent blood clots from forming in people who have both atrial fibrillation and acute coronary syndrome. Plavix for prevention or treatment of deep vein thrombosis not an appropriate use. Plavix is not approved to treat or prevent deep vein thrombosis DVT. Plavix is not approved to treat elevated cholesterol. Plavix is often prescribed in combination with other drugs. Note: Some of the drugs listed below are used off-label. Plavix is often prescribed in combination with aspirin to treat various conditions.
The combination of Plavix and aspirin is called dual antiplatelet therapy. This is because both drugs work to stop your platelets from sticking together and forming dangerous clots. Several studies have shown a benefit to using these drugs together rather than taking either of the drugs alone.
Plavix is FDA-approved for use in combination with aspirin to prevent heart attack and stroke in people with acute coronary syndrome ACS. Plavix may be used in combination with an anticoagulant blood thinner in some people who have conditions such as atrial fibrillation, or in people who have very high risk of a cardiovascular event. Cardiovascular events include heart attack and stroke. The following information describes dosages that are commonly used or recommended.
However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs. The typical dosage of Plavix for acute coronary syndrome ACS depends on whether you have:. The typical dosage of Plavix is one mg tablet taken by mouth once daily.
It can be taken with or without food. Your doctor may recommend that you start Plavix therapy by taking a loading dose. With a loading dose, the drug is given to you at a dosage higher than the typical dosage. A loading dose is used to increase the level of the drug in your body right away. The typical loading dosage of Plavix is mg four mg tablets or one mg tablet taken by mouth one time.
After taking your loading dose of Plavix, your doctor will recommend the dosage of Plavix that you should continue to take each day. The typical dosage of Plavix for people with peripheral artery disease PAD , recent stroke , or recent heart attack is one mg tablet taken by mouth once daily.
If you miss a dose of Plavix, try to take it as soon as you remember. Doing this may increase your risk of serious side effects. A medication timer may be useful, too. You might. Plavix is meant to be used as a long-term treatment. Other drugs are available that can reduce your risk of cardiovascular events, such as heart attack and stroke.
Some may be better suited for you than others. They can tell you about other medications that may work well for you. The drugs listed below all help to prevent your body from making too many blood clots. However, these drugs each work in slightly different ways. Because of this, some drugs may work better for you than other drugs. Note: Some of the drugs listed above are used off-label.
You may wonder how Plavix compares to other medications that are prescribed for similar uses. Here we look at how Plavix and Brilinta are alike and different. Plavix contains the drug clopidogrel, while Brilinta contains the drug ticagrelor. These drugs belong to the same class of medications called platelet inhibitors. Plavix and Brilinta are both approved to prevent cardiovascular complications, such as heart attack and stroke , in people who have acute coronary syndrome ACS.
This syndrome is caused by a lack of blood flow to your heart due to a blockage. Unstable angina a type of chest pain and heart attack are two types of ACS.
Both Plavix and Brilinta are often prescribed for use in combination with aspirin. Plavix comes as tablets that are taken by mouth once each day. Brilinta comes as tablets that are taken by mouth twice each day. There is also a loading dose for Brilinta. Plavix and Brilinta belong to a class of drugs called platelet inhibitors. Therefore, both medications can cause very similar side effects. Below are examples of these side effects. These lists contain examples of more common side effects that can occur with Plavix, with Brilinta, or with both drugs when taken individually.
You may not feel any different after you start taking clopidogrel. However, this does not mean that the medicine is not working. Carry on taking clopidogrel even if you feel well, as you'll still be getting the benefits. You may need to take clopidogrel for a few weeks or months, or you may have to take it for the rest of your life.
Clopidogrel is generally safe to take for a long time. In fact, it works best if you take it for many months or even years. If you're at risk of getting a stomach ulcer, your doctor may prescribe a medicine to help protect your stomach while you're taking clopidogrel.
If you stop taking clopidogrel, your blood will start clotting at the same rate as before you started taking it, usually within 5 days of stopping the medicine.
This means you may be at increased risk of serious problems like heart attacks or strokes. Other antiplatelet medicines include low-dose aspirin , dipyridamole and ticagrelor. Anticoagulant medicines such as apixaban , dabigatran , edoxaban , rivaroxaban and warfarin are also prescribed to prevent blood clots forming. Talk to your doctor or pharmacist to find out why you have been recommended a particular medicine. Both clopidogrel and ticagrelor work to:.
But ticagrelor is not approved for preventing further strokes if you have already had a stroke. In this case, your doctor may prescribe clopidogrel instead.
You'll usually take clopidogrel once a day. Ticagrelor is taken twice a day. Yes, you can drink alcohol while taking clopidogrel, as long as you stick to the national guidelines of no more than 14 units a week for men and women. A standard glass of wine ml is 2 units. A pint of lager or beer is usually 2 to 3 units of alcohol. Drinking too much alcohol while you're taking clopidogrel can irritate your stomach.
There's a risk that you could get a stomach ulcer. Grapefruit juice decreases the effects of your medicine, so that it may not work as well to prevent clots.
Because of the risk of bleeding, you may need to stop taking clopidogrel for a short time before having surgery or dental work. Do not stop taking clopidogrel without first talking to your doctor or dentist.
They'll tell you if you need to stop taking clopidogrel before a procedure. It's a good idea to mention to the doctor or nurse that you're taking an antiplatelet medicine. Clopidogrel does not affect any type of contraception, including the combined pill and emergency contraception. There's no clear evidence to suggest that taking clopidogrel will reduce fertility in either men or women.
But speak to a pharmacist or your doctor before taking it if you're trying to get pregnant. Clopidogrel does not affect your concentration, so you can drive or ride a bike while you're taking it. If you have been prescribed clopidogrel, you can also boost your health by making some key lifestyle changes. Page last reviewed: 5 August Next review due: 5 August Clopidogrel - Brand names: Grepid, Plavix On this page About clopidogrel Key facts Who can and cannot take clopidogrel How and when to take clopidogrel Side effects How to cope with side effects of clopidogrel Pregnancy and breastfeeding Cautions with other medicines Common questions about clopidogrel.
About clopidogrel Clopidogrel is an antiplatelet medicine. Your risk is higher if you have or have had: a heart attack unstable angina a stroke or "mini-stroke" transient ischaemic attack or TIA peripheral arterial disease an operation on your heart or blood vessels, such as a coronary stent insertion Clopidogrel comes as tablets and is only available on prescription.
Help us improve our website Can you answer a quick question about your visit today? The usual dose for clopidogrel is 75mg once a day. Your doctor may prescribe clopidogrel with or instead of low-dose aspirin. The main side effect of clopidogrel is bleeding more easily than normal. You may have nosebleeds, heavier periods, bleeding gums or bruising. You can drink alcohol with clopidogrel. But do not drink too much while taking this medicine.
It can irritate your stomach. You may need to stop taking clopidogrel for a short time before having surgery or dental treatment, but check with your doctor or dentist first. Clopidogrel can be taken by adults aged 18 and over. To make sure this medicine is safe for you, tell your doctor if you: have ever had an allergic reaction to clopidogrel or any other medicine have a stomach ulcer or have had stomach ulcers in the past have had bleeding in your brain a brain haemorrhage have a bleeding disorder, such as haemophilia have liver or kidney problems are trying to get pregnant, already pregnant or breastfeeding.
You can take clopidogrel with or without food. Dosage The usual dose is 75mg a day. What if I forget to take it? If you forget to take clopidogrel, take it as soon as you remember. Do not take a double dose to make up for a forgotten dose.
What if I take too much? Taking 1 or 2 extra tablets is unlikely to harm you. Common side effects These common side effects happen in more than 1 in people. Talk to your doctor or pharmacist if these side effects bother you or do not go away: bleeding more easily than normal — nosebleeds, bruising more easily or bleeding that takes longer to stop diarrhoea stomach pain indigestion or heartburn Serious side effects Serious side effects are rare and happen in less than 1 in 1, people.
Call a doctor as soon as possible if: you're coughing up blood, or there's blood in your pee, poo or vomit the whites of your eyes turn yellow, or your skin turns yellow, although this can be harder to see on brown or black skin — these can be signs of liver problems you feel very tired or have signs of infections, such as a high temperature or sore throat — these can be signs of a blood or bone marrow disorder Serious allergic reaction In rare cases, clopidogrel can cause a serious allergic reaction anaphylaxis.
The first was an analysis of cancer-related adverse events from four trials with information on cancer adverse events 37, patients that compared long-term use of clopidogrel and aspirin to use of either aspirin alone or short-term clopidogrel plus aspirin. The incidence of cancer adverse events was 4. The second trial-level meta-analysis was performed to assess cancer-related death and included five trials with information on cancer deaths 40, patients.
The incidence of cancer death was 0. The findings from the DAPT trial with regard to cancer-related adverse events increased for prasugrel, but not for clopidogrel and cancer-related death increased for clopidogrel, but not for prasugrel have not been observed in our analyses of other randomized-controlled clinical trials.
Our reviews found no evidence of either a harmful or beneficial effect of clopidogrel on overall mortality in a population with, or at risk for, coronary artery disease, and no effect on cancer.
Safety Announcement. The following table shows the results from the meta-analyses: Number of patients included Long-term clopidogrel plus aspirin Short term clopidogrel plus aspirin or aspirin alone Overall incidence of death 56, 6. Facts about Clopidogrel.
Clopidogrel is an antiplatelet medicine used to reduce the risk of heart attacks, strokes, and other clot-related conditions in patients who have had a previous heart attack, stroke, or problems with the circulation in the arms and legs. It works by keeping the platelets in the blood from sticking together, thereby preventing blood clots that can occur with certain cardiovascular conditions.
Clopidogrel is sold under the brand name Plavix and as generics. Clopidogrel increases the risk of bleeding. Taking clopidogrel with certain medicines may increase your risk of bleeding. Tell your health care professional if you take any of the following: Aspirin, especially if you have had a stroke. Always ask your health care professional about whether you should take aspirin with clopidogrel to treat your condition. Warfarin Coumadin, Jantoven. Other common side effects of clopidogrel can include shortness of breath.
Additional Information for Patients and Caregivers. Based on our reviews of the Dual Antiplatelet Therapy DAPT trial and several other large clinical trials, we have concluded that treatment with clopidogrel does not appear to change the overall risk of death in patients with, or at risk for, coronary artery disease. Clopidogrel is an antiplatelet blood-thinning medicine that may help prevent future heart attacks, strokes, and other clot-related diseases in patients who have already had a heart attack, stroke, or have certain cardiovascular conditions.
Do not stop taking clopidogrel without first talking to your health care professional. Suddenly stopping the use of antiplatelet medicines can put you at risk for heart attacks, strokes, and blood clots. Be aware that while taking clopidogrel you may bruise more easily, and it may take longer for any bleeding to stop. Discuss any questions or concerns about clopidogrel with your health care professional.
Read the patient Medication Guide you get along with your clopidogrel prescriptions. It explains the benefits and risks associated with the use of clopidogrel. Additional Information for Health Care Professionals. Based on our reviews of the Dual Antiplatelet Therapy DAPT trial and several other large, long-term clinical trials, we have concluded that there is no evidence of either a harmful or beneficial effect of clopidogrel on all-cause mortality or cancer-related deaths in a population with, or at risk for, coronary artery disease.
That is, the adverse mortality findings in the DAPT trial were not confirmed. Clopidogrel is approved for use in combination with aspirin in patients with acute coronary syndrome, or in patients not on aspirin with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease. When selecting antiplatelet therapy for patients with an acute coronary syndrome who are managed with coronary stent implantation, prescribers should consider that prasugrel and ticagrelor have been shown to be superior to clopidogrel when used in this patient population.
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